Our Focus
Allied BioNutrition’s Nutraceutical biotechnology focuses on revolutionary science that may impact the lives of millions of people worldwide. Our biotechnology utilizes a clinically-based, field-proven, proprietary flavonoids extract from the polyphenol family which features unmatched antioxidation characteristics uniquely formulated for cardiovascular health.
After years of research and clinical trials, we were able to demonstrate and clinically validate the high efficacy of our biotechnology on LDL cholesterol oxidation and its drastic impact on arterial health and blood circulation as well as other cardiovascular parameters that are critical to our health.
Allied BioNutrition’s biotechnology truly presents a clinically proven “think-out- of-the- box” approach to cardiovascular health management.
Study Results: Flavonoids Root Extract Reduces Oxidation
In April 2016, the results from our double-blind, placebo-controlled study were published in the scientific journal Food and Nutrition Research. The study examined the effect of our unique Flavonoids Root Extract on the thickness of the artery wall (carotid intima-media thickness or CIMT) in individuals with oxidation in the arteries. CIMT is considered a strong biomarker of overall cardiovascular and arterial health.
People with increased oxidation in the arteries, total cholesterol greater then 240mg/dL, were randomly allocated to 2 groups as follows: an experimental group that received 200mg of the flavonoids root extract and a placebo group. 110 participants were initially allocated to the 2 groups. After some withdrawals, 94 subjects ultimately completed the trial. After 1 year, the study yielded the following results:
In the experimental group the thickness of artery (CIMT) decreased from 0.92 mm to 0.84 mm. In the placebo group CIMT increased from 0.85 to 0.88.
In the experimental group total cholesterol decreased from 284 to 262 mm/dL. In the placebo group total cholesterol decreased from 291 to 289mm/dL.
In the experimental group the LDL (bad) cholesterol decreased from 183 to 173 mm/dL. In the placebo group the LDL (bad) cholesterol increased from 177 to 179.
HDL or good cholesterol did not change in either group.
In the experimental group systolic blood pressure decreased from 138 to 125mmhg. In the placebo group systolic blood pressure increased from 136 to 137.
In the experimental group diastolic blood pressure decreased from 92 to 84. In the placebo group diastolic blood pressure increased from 89 to 90.
These results were extremely compelling. Following one year of Flavonoids Root Extract consumption, mean CIMT, total cholesterol, LDL levels, and blood pressure decreased. This suggests that this ingredient may attenuate the development of oxidation and of related cardiovascular problems.
Pilot Market Sees Great Success
In 2016, Allied BioNutrition announced its Nutraceutical biotechnology consisting of a proprietary Flavonoids Root Extract. This extract has unmatched antioxidant properties that has been clinically validated for its cardiovascular health benefits. It has been successfully used by thousands of consumers over many years in a predetermined pilot market. Most of these consumers used this proprietary Flavonoids Root Extract on a daily basis and experienced profound cardiovascular health benefits. In 2017, Allied BioNutrition will officially launch a growing family of Nutraceutical dietary supplements, bringing this extraordinary Flavonoids antioxidant biotechnology, with all its unique cardiovascular health benefits, to the world.
Glycyrrhiza glabra: An Untold Story
Glycyrrhiza glabra, the focus of Allied BioNutrition’s biotechnology, has a long history of use by cultures throughout the world, including the Greeks, Egyptians, Chinese and Hindus. It grows wild in southern and central Europe and is extensively cultivated in Russia, Spain, Persia and India. Glycyrrhiza glabra is widely used as a flavoring, not only for candy, but also in cough drops, syrups, tonics and laxatives.
The root of Glycyrrhiza glabra has been used for centuries as antidotes, demulcents, expectorants, and remedies for allergic inflammation, as well as flavoring and sweetening agents in Asia and Europe. Glycyrrhiza glabra contains glycyrrhizin, oleane triterpenoids, glucose, and a range of flavonoids from the polyphenol family. It has been used in folk medicine for addressing various disorders. Glycyrrhiza glabra has the biological capabilities of detoxification, antioxidation, and anti-infection.
Antioxidants Promote Cardiovascular Health
Oxidative modification of low-density lipoprotein (LDL) in the arterial wall plays a key role in the pathogenesis of the arterial wall. Under oxidative stress, LDL is exposed to oxidative modifications by arterial wall cells, including macrophages. Oxidative stress also induces cellular-lipid peroxidation, resulting in the formation of ‘oxidized macrophages’, which demonstrate increased capacity to oxidize LDL and increased uptake of oxidized LDL(2). Macrophage-mediated oxidation of LDL depends on the balance between pro-oxidants and antioxidants in the lipoprotein and in the cells. LDL is protected from oxidation by antioxidants. A large number of studies provide data suggesting that consumption of dietary antioxidants is associated with promoting cardiovascular health. Basic research provides plausible mechanisms by which dietary antioxidants might reduce the development of oxidation. These mechanisms include inhibition of LDL oxidation, inhibition of cellular lipid peroxidation and consequently attenuation of cell-mediated oxidation of LDL. The Flavonoids root includes potent polyphenolic flavonoids.
Interestingly, consumption of some plant-derived flavonoids results in their absorption and appearance in plasma and tissues. The inverse relationship between dietary flavonoids consumption and cardiovascular problems may be associated with the ability of flavonoids to attenuate LDL oxidation, macrophage foam cell formation, and increased oxidation. The effect of flavonoids on arterial cell-mediated oxidation of LDL is determined by their accumulation in the lipoprotein and in arterial cells, such as macrophages. Flavonoids can reduce LDL lipid peroxidation by scavenging free radicals, chelation of transition metal ions and sparing of LDL-associated antioxidants.
Glabridin: A Key Component of Flavonoids Extract
Glabridin is a polyphenolic flavonoid and is a main constituent of Allied BioNutrition’s proprietary flavonoids extract. Glabridin has a wide range of biological activities, including inhibiting the growth of microorganisms, protecting against oxidation, promoting kidney health, and promoting cardiovascular protective activities. Recently, according to various studies, Glabridin has shown a unique protective effect on low-density lipoprotein oxidation, which could be attributed to the powerful antioxidation effect of Glabridin. It is also well known for its beneficial effects on the skin through an inhibitory effect on melanogenesis and inflammation.
Flavonoids are also known to have an anti-inflammatory effect. Various components of flavonoids, including glabridin, are involved in this effect by exerting an inhibitory effect on cyclooxygenase and lipoxygenase activities.
Allied BioNutrition recently hired an independent Analytical Lab to conduct a comprehensive analysis of its proprietary flavonoids extract comparing it with other Glycyrrhiza glabra extract products currently on the market. The results of this independent analysis has unequivocally determined that AlliedBioNutrition’s proprietary flavonoids extract product has 10 times the concentration of Glabridin than these other products. This fact can be attributed to the unique extraction process implemented by AlliedBioNutrition during the manufacturing of its dietary supplements.
Study Shows the Efficacy of Flavonoids
In a human study at the Lipid Research Laboratory, Technion Faculty of Medicine Rambam Medical Center, Haifa, the proprietary Flavonoids Root Extract used in Allied BioNutrition’s products was supplemented to hypercholesterolemic patients over a period of one month, followed by an additional month of placebo consumption. The study produced the following results:
- Reduced patients’ plasma susceptibility to oxidation by 19%
- Increased resistance of plasma LDL against three major oxidation biomarkers:
LDL oxidation (by 55%)
Aggregation (by 28%)
Retention, estimated as chondroitin sulfate binding ability, by 25%
The unique flavonoids component of Allied BioNutrition’s Nutraceutical products has shown one major strength: a significant impact on oxidation of plasma and, in particular, LDL Cholesterol.
In recent years, more and more scientists and medical experts from around the world have conducted clinical trials on LDL oxidation. It is now becoming evident in the medical world that LDL oxidation is a major factor impacting blood circulation in the peripheral arteries and general cardiovascular health.
The Origins of Our Proprietary Flavonoids Root Extract
A team of prominent Israeli scientists in the areas of oxidative stress and antioxidants focusing on dietary polyphenols and paraoxonases were the first to elucidate the mechanisms behind the protection against plasma oxidation. This was first shown by the consumption of red wine or pomegranate juice (POM), and then through the cardio-protection of the antioxidant enzyme, paraoxonases (PON), which breaks down harmful oxidized lipids.
After several years of research, the Israeli research team discovered that Flavonoids Root Extract, formulated via a unique process from the roots of the Glycyrrhiza Glabra plant, can reduce LDL cholesterol oxidation in the blood of humans by 55%, as well as provides a wide range of cardiovascular health benefits.
Allied BioNutrition took these discoveries one step further. Our 2016 clinical trial revealed that this unique Flavonoids extract may contribute not only to a significant reduction of LDL oxidation in plasma, but goes beyond that and promotes removal of oxidized cholesterol that has accumulated over years in the arteries. This is a major step forward in promoting cardiovascular health and, in particular, heart health.
